Hypotheses in the Life Sciences

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Hypotheses in the Life Sciences is undergoing a change of publisher and is not currently accepting submissions through the web site any more.

Further information will be posted once arrangements have been finalised.

 
Posted: 2014-03-28
 

Radical new solution to the gaps and inconsistencies in the current understanding of the mechanism of haem-centred NOS catalysis

 
This paper offers a radical, new solution to the gaps and inconsistencies in the current understanding of the mechanism of haem-centred NOS catalysis, which also challenges the other existing paradigm of cobalamin as just an .NO mop. Examination of a wide diversity of NOS and cobalamin-dependent enzyme structure-function studies, as well as data from the .NO/cobalamin chemical, biochemical, immunological, genetic, and clinical literature, offers indications that cobalamin, specifically, in one of its active forms, adenosylcobalamin (AdoCbl), may have a third, eukaryotic coenzyme function as the principal cofactor of well-regulated NOS catalysis in vivo.  
Posted: 2012-10-29
 
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Vol 3, No 1 (2013)

Table of Contents

Articles

Hypotheses evolving. PDF
William Bains 1
Application of a Hypothesis to Speciation in Hominidae PDF
George Edward Parris 2-5
Nutrient Loading Increases Red Snapper Production in the Gulf of Mexico PDF
Joshua M. Courtney, Amy C. Courtney, Michael W. Courtney 7-14
Possible roles of sphingolipids in clathrin-mediated endocytosis - Vesicle formation by a glycerophospholipid cycle - a hypothesis PDF
Sybille G. E. Meyer 15-22


ISSN: 2042-8960